Influenza and the challenge for immunology
Identifieur interne : 001544 ( Main/Exploration ); précédent : 001543; suivant : 001545Influenza and the challenge for immunology
Auteurs : Peter C. Doherty [Australie, États-Unis] ; Stephen J. Turner [Australie] ; Richard G. Webby [États-Unis] ; Paul G. Thomas [États-Unis]Source :
- Nature Immunology [ 1529-2908 ] ; 2006-05.
Abstract
The continued westward dissemination of H5N1 influenza A viruses in avian populations and the nearly 50% mortality rate of humans infected with H5N1 are a source of great international concern. A mutant H5N1 virus with the capability to spread rapidly between humans could cause a global catastrophe. Governments have reacted by developing national response plans, stockpiling antiviral drugs and speeding up the development and approval of vaccines. Here we summarize what is known about the interaction between influenza A viruses and the mammalian host response, specifically emphasizing issues that might be of interest to the broader immunology community.
Url:
DOI: 10.1038/ni1343
Affiliations:
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Doherty</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Microbiology and Immunology, University of Melbourne School of Medicine, Victoria 3010</wicri:regionArea><wicri:noRegion>Victoria 3010</wicri:noRegion></affiliation><affiliation wicri:level="2"><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Australie</country></affiliation></author><author><name sortKey="Turner, Stephen J" sort="Turner, Stephen J" uniqKey="Turner S" first="Stephen J" last="Turner">Stephen J. 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A mutant H5N1 virus with the capability to spread rapidly between humans could cause a global catastrophe. Governments have reacted by developing national response plans, stockpiling antiviral drugs and speeding up the development and approval of vaccines. Here we summarize what is known about the interaction between influenza A viruses and the mammalian host response, specifically emphasizing issues that might be of interest to the broader immunology community.</div></front></TEI><affiliations><list><country><li>Australie</li><li>États-Unis</li></country><region><li>Tennessee</li></region></list><tree><country name="Australie"><noRegion><name sortKey="Doherty, Peter C" sort="Doherty, Peter C" uniqKey="Doherty P" first="Peter C" last="Doherty">Peter C. Doherty</name></noRegion><name sortKey="Doherty, Peter C" sort="Doherty, Peter C" uniqKey="Doherty P" first="Peter C" last="Doherty">Peter C. 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